BIOL133 Week 13 Lab Assignment 8 - DNA & RNA; Exercise
Course : American Public
Contributed : May Anderson
- $20.00
Exploration
- The nucleotides in DNA pair via:
- The nucleotides in DNA pair via:
- The nucleotides in DNA pair via:
- Where does translation take place in a cell?
- Which type of mutation has no effect on protein function?
Exercise 1
- How long are each of your peptide chains (how many amino acids are present)?
- What differences exist between your two transcripts? What about your translated product?
- Hb A represents a section of the 626 base normal hemoglobin beta mRNA sequence. Hb S is from the sickle cell hemoglobin. Is the mutation found in sickle cell hemoglobin a point mutation or a frameshift mutation?
- Does the sickle cell mutation result in a missense mutation, silent mutation or nonsense mutation? Why?
- What is the resulting new trait for this mutation? What are the resulting symptoms in people with the HbS hemoglobin protein?
- Do a web-search to find another example of a disease caused by a mutation in a single gene. Do the resulting symptoms (new trait) make sense considering the role of the affected protein? Why or why not?
Exercise 2
- How does each of your mutations affect the amino acid sequences? Are the mutations missense mutations, silent mutations or nonsense mutations?
- What differences did you notice between the point mutation and the frameshift mutations?
- Is it possible to determine the DNA sequence from the amino acid sequence Leu Pro Arg? Why or Why not?
Competency Review
- Which of the following accurately describes transcription and translation?
- Which of the following accurately defines the terms and has them in the correct order of occurrence in the cell?
- Which of the following is not a component of DNA?
